Navir HT32386 Stellarscope, Black, Multicoloured

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Northern and southern hemisphere star maps with over 1500 stars identified (the brightest are labelled by name) Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol. 2011;29:644–52. Shao W, Wang T. Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data. Genome Res. 2021;31:88–100. There are 2 maps that can be installed; one for the northern hemisphere, and one for the southern hemisphere. There are 4 masks included, which represent your horizon at a particular lattitude. They cover the ranges 20*-30*, 30*-40*, 40*-50*, and 50*-60*

Besides broad HERV activity that has been detected in reproductive tissues [ 47], our study highlights the involvement of hervRNAs in brain development. We found that hervRNAs are abundantly expressed in the brain, at levels second only to those in the testis. On the other hand, our cis-ervQTL analysis revealed a strong association between hervRNAs and brain diseases including neurodegenerative and psychiatric diseases. In addition, hervRNAs that show decreased levels with age are also significantly enriched in the brain, especially the hippocampus. As chronic activation of mouse ERV is associated with hippocampus-based memory impairment [ 48], hervRNAs may also exert functions in human memory and cognition. We also found that hervRNAs are preferentially expressed in the cerebellum, and hervRNAs in the cerebellum are associated with amyotrophic lateral sclerosis, implying that hervRNAs may be involved in cerebellum function. Together, our study suggests that hervRNAs may be involved in brain development as well as cognition. Additionally, the identification of sex-biased and ethnicity-biased hervRNAs in the brain might further our understanding of sex and ethnicity differences in brain structure and function [ 49, 50]. Wang L, Park HJ, Dasari S, Wang S, Kocher JP, Li W. CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model. Nucleic Acids Res. 2013;41:e74. Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014;10:e1004383. The Galilean telescope goes by that name because it is the same design Galileo Galilei used to discover the four big moons of Jupiter and other astronomical objects. 7. How to find Saturn with my telescope?This clever scope is able to see clearly as far as Saturn, and can even show you the Crab Nebula M82 and M81 Attig J, Young GR, Hosie L, Perkins D, Encheva-Yokoya V, Stoye JP, et al. LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly. Genome Res. 2019;29:1578–90. Zhang Y, Li T, Preissl S, Amaral ML, Grinstein JD, Farah EN, et al. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nat Genet. 2019;51:1380–8. If you throw yourself in at the deep end, and expect to seeing deep space nebulae and close up views of Saturn’s rings on your first excursion, you too may end up disappointed! Mi S, Lee X, Li X, Veldman GM, Finnerty H, Racie L, et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature. 2000;403:785–9.

Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921.First, RNA-seq data were aligned to the reference human genome (GRCh38) using STAR v2.7.5c [ 53] with Gencode v31 [ 54] for gene annotation. Reads that mapped to the HERV regions annotated by the HERVd database [ 55, 56] but did not overlap with transcripts in Gencode were extracted with sambamba v0.6.6 [ 57] and de novo assembled with Trinity v2.1.1 [ 58, 59]. The assembled transcripts were quantified using align_and_estimate_abundance.pl in Trinity and remapped to the reference human genome using GMAP version 2020-06-30 [ 60]. The assembled transcripts with a count > 5 and identity ≥ 96% relative to the reference genome were retained for meta-assembly performed by TACO v0.7.3 [ 61]. Then, merged HERV candidates identified in ≥ 50% of samples and with a length of ≥ 200 bp were remapped to the reference genome with GMAP. The genes that were uniquely mapped to the HERV loci were retained as candidate HERV genes. Finally, RNA-seq data were realigned to the reference human genome using STAR with the combination of Gencode GTF and the candidate HERV annotations for downstream HERV quantification. HERV expression was calculated at the gene level using RSEM v1.2.28 [ 62], which is adapted for repeat element quantification. HERVs with a raw count > 5 and TPM ≥ 0.1 [ 52] among ≥ 50% of samples were considered to be expressed. Cell culture and RNA isolation Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–75.